• Kidney transplant received ≥ 6 months

• Active or chronic active AMR according to Banff 2022 classification, based on Screening kidney biopsy

• Either positive C4d on Screening kidney biopsy based on the Central Pathology Laboratory report and/or positive HLA Class I and/or II antigen-specific DSA as determined by the local laboratory's definition of positivity using single-antigen bead based assays

• MVI score ≥ 2 (g ≥ 1 and ptc ≥ 1)

• eGFR ≥ 30 mL/min/1.73 m2

• Must be vaccinated against meningococcal infection from serogroups A, C, W, Y (and B where available) at least 14 days prior to but no more than 3 years prior to Day 1

• Must be vaccinated for S pneumoniae prior to randomization

• Must be vaccinated for H influenzae type B (where available) prior to randomization

• Body weight ≥ 50 kg at Screening